Journal: Quantitative Imaging in Medicine and Surgery

Article Title: The utility of multi-b-value diffusion and arterial spin labelling magnetic resonance imaging in gliomas grading and prediction of isocitrate dehydrogenase status

doi: 10.21037/qims-2025-1182

Figure Lengend Snippet: Multi-b and ASL MRI examination in a patient with HGG. MRI examination in 62-year-old women with HGG (glioblastoma grade 4, IDH wild-type) located in medial rostral part of the right occipital lobe depicted as an enhancing mass in T1 weighted axial image (A). Maps of D—diffusion coefficient (B), D*—pseudo-diffusion (C), f—perfusion fraction (D), FLAIR image (E), CBF (f), fD* (G) and K (H) are shown. High signal intensity in FLAIR image and hyper-vascularized rim is well visible in ASL (CBF) image as well as in D* and fD* maps. Comparatively high values were observed also for f and K parameters. Map of D shows a spot of restricted diffusivity. Mean K and D* values measured within the tumour were 0.834 and 10,465 (10−6 mm 2 /s), respectively. ASL, arterial spin labelling; CBF, cerebral blood flow; FLAIR, fluid attenuated inversion recovery; HGG, high-grade glioma; IDH, isocitrate dehydrogenase; MRI, magnetic resonance imaging.

Article Snippet: Examples of multi-b parameter maps and 3D volumes of interests (VOIs) in patients with gliomas are presented in .ASL normalization by proton density-weighted images as well as CBF maps were calculated automatically by hardware-related Philips software.

Techniques: Diffusion-based Assay, Magnetic Resonance Imaging

Journal: Quantitative Imaging in Medicine and Surgery

Article Title: The utility of multi-b-value diffusion and arterial spin labelling magnetic resonance imaging in gliomas grading and prediction of isocitrate dehydrogenase status

doi: 10.21037/qims-2025-1182

Figure Lengend Snippet: Multi-b and ASL MRI examination in a patient with LGG. MRI examination in a 41-year-old man with diffuse astrocytoma (grade 2, IDH-mutated). The tumour located in the right frontal lobe in axial T1 weighted axial image (A) is hypointense with tiny spots of enhancements in central part. Maps of D—diffusion coefficient (B), D*—pseudo-diffusion (C), f—perfusion fraction (D), FLAIR image (E), CBF (F), fD* (G) and K (H) are shown. High signal intensity is seen in FLAIR image. The diffusivity of the tumour is high, as depicted on D map. Perfusion visible on CBF map is low, as are D*, fD*, and K values, as depicted on parametric maps, and f values are comparatively high. Mean K and D* values measured within the tumour were 0.452 and 4,817 (10 −6 mm 2 /s), respectively. ASL, arterial spin labelling; CBF, cerebral blood flow; FLAIR, fluid attenuated inversion recovery; IDH, isocitrate dehydrogenase; LGG, low-grade glioma; MRI, magnetic resonance imaging.

Article Snippet: Examples of multi-b parameter maps and 3D volumes of interests (VOIs) in patients with gliomas are presented in .ASL normalization by proton density-weighted images as well as CBF maps were calculated automatically by hardware-related Philips software.

Techniques: Diffusion-based Assay, Magnetic Resonance Imaging